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Cyclophosphamide interferes with oogenesis and spermatogenesisIt may cause sterility in both sexesDevelopment of sterility appears to depend on the dose of cyclophosphamideduration of therapyand the state of gonadal function at the time of treatmentCyclophosphamide-induced sterility may be irreversible in some patients.
When Cytoxan is included in combined cytotoxic regimensit may be necessary to reduce the dose of Cytoxan as well as that of the other drugs.
No residual cardiac abnormalitiesas evidenced by electrocardiogram or echocardiogram appear to be present in patients surviving episodes of apparent cardiac toxicity associated with high doses of cyclophosphamide.
Since this drug can be absorbed through the skin and lungs and may harm an unborn babywomen who are pregnant or who may become pregnant should not handle this medication or breathe dust from the tablets or capsules.
Neutropenia occurs in patients treated with CytoxancyclophosphamideThe degree of neutropenia is particularly important because it correlates with a reduction in resistance to infectionsFever cheap benemid medication without documented infection has been reported in neutropenic patients.
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